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KMID : 0359819950240060631
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Journal of Korean Neurosurgical Society
1995 Volume.24 No. 6 p.631 ~ p.639
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The Neuroprotective Effects of Phenytion on Ischemic-hypoxic Injury to the Developing Rat Brain
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김영백
박언섭/안영환/박관/민병국/황성남/석종식/최덕영
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Abstract
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Phenytoin is an anticonvulsant compound which modulates the voltage-dependent sodium channels. It has a neuroprotective effect in vitro against hypoxic damage in hippocampal slices of adult rats.
The authors studied the efficasy of phenytion on cerebral ischemia in an vivo model of hypoxic-ischemic brain injury in developing rat brain. to elicit injury. 7 days old (P7) Spraguedawley rats subjected to right common carotid ligation followed
by 8%
O2 exposure (humidified, balanced with nitrogen) for 3hours under the halothane anesthesia (control group. N=58). Body temperature of the rats was accurately controlled before and during hypoxia. Before hypoxia, pups received intraperitoneal
phenytoin
(30mg/kg) (phenytoin-treated group. N=17). The animals were sacrificed one week later and histopathological evaluation of ischemic neuronal damage were conducted employing hematoxylin-eosin staining and measurement of the the hemispheric weight
differences were performed.
Phenytoin was found to be effective in reducing neuronal damage in terms of weight comparison (24±2.4% atrophy of control vs. 5±2.9% atrophy of phenytoin group, p<0.001) and ischemic changes in hippocampal region (p<0.05) in CA1, CA2, and CA3
area).
These data suggest that compounds like phenytoin, which modulates voltage-dependent sodium channels, can reduce the degree of injury from hypoxic-ischemic insults to the developing rat brain.
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